Folate & MTHFR: Effects on Brain Health

​In this lecture, Functional & Metabolic Psychiatry expert Dr. James Greenblatt examines the well-researched connections between MTHFR mutations and mental health, and discusses the extraordinary value of incorporating MTHFR gene testing into the modern therapeutic arsenal. After reviewing the biological roles of folate, Dr. Greenblatt will review the most common MTHFR gene variants – “T” and “C” – and the metabolic impacts of heterozygous vs. homozygous presentations on MTHFR enzyme function. Studies demonstrating robust associations between MTHFR variants and various psychiatric outcomes will also be presented.

​Finally, Dr. Greenblatt will present evidence-based recommendations for the comprehensive assessment of folate and MTHFR status, as well as strategies for folate supplementation to support optimal brain health.

​By the end of this presentation, attendees will be able to:

• ​Understand the functional differences between folate, folic acid, and L-methylfolate

• ​Explain the function of the MTHFR enzyme

• ​Describe two or more biological functions of folate as pertain to brain function and/or neurotransmission

• ​Describe the effects of heterozygous vs. homozygous C677T and A1298C mutations on MTHFR enzyme activity

• ​Elucidate the potential therapeutic benefits of MTHFR genetic testing in psychiatric patients

• ​Understand how to initiate a regimen of folate supplementation tailored to individual need on the basis of test results