Chiara Herzog | What the epigenome remembers: ageing, disease risk, and the tissues we overlook
Biotech and Health Extension sponsored by 100 Plus Capital
What the epigenome remembers: ageing, disease risk, and the tissues we overlook
Bio: Dr. Chiara Herzog is a King’s Prize Fellow (junior group leader) at King’s College London, where she investigates how the epigenome can be harnessed to better understand ageing and predict disease risk. She is an inventor on multiple patents that leverage the epigenome for disease risk prediction, and has developed a clinically available test for endometrial cancer detection. Her contributions to the field have been recognised with several prestigious awards. Dr. Herzog serves on the executive committee of the Biomarkers of Aging Consortium (https://www.agingconsortium.org/) and founded the London Ageing Research Network to connect local researchers across disciplines (https://www.londonageingresearch.com/).
Abstract: DNA methylation is a dynamic layer of molecular information that sits on top of our genetic code (DNA), shaping how genes are expressed and changing in response to age, lifestyle, and environmental exposures. In this talk, I will explore how DNA methylation can be leveraged to reconstruct an individual’s biological history, quantify ageing, and predict future disease risk. I will highlight emerging applications of epigenetic biomarkers in health research and discuss findings from large-scale studies, including the multi-omic TirolGESUND study. While blood has traditionally been the sample of choice for such analyses, I will make the case for broadening our approach, showing why alternative tissues such as saliva or buccal swabs may offer unique advantages in specific contexts. By rethinking our sampling strategies, we can unlock new opportunities for early detection, personalised prevention, and more accessible health prediction.
Biotech and Health Extension sponsored by 100 Plus Capital
A group of scientists, entrepreneurs, funders, and institutional allies who cooperate to advance biotechnology to reverse aging and extend human healthspan. This group is sponsored by 100 Plus Capital.
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Zoom link: https://us02web.zoom.us/j/87184473255